7-(HYDROXY LOWER ALKYL)BENZODIAZEPINE DERIVATIVES
Cpds. (I):- (where B is CH2 or CO; R1, R2, R3 and R4 is H, or 1-7C alkyl; R5 is H or halogen; R6 and R7 are H or together a supplementary C-N-bond, are prepd. by cyclisation of the acetanilide, reduction of the 7-acyl cpds., oxidn. of the 4,5-hydro-deriv., reduction of the 4,5-double bond or by repl...
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| creator | YE FONG NING R STERNBACH L |
| description | Cpds. (I):- (where B is CH2 or CO; R1, R2, R3 and R4 is H, or 1-7C alkyl; R5 is H or halogen; R6 and R7 are H or together a supplementary C-N-bond, are prepd. by cyclisation of the acetanilide, reduction of the 7-acyl cpds., oxidn. of the 4,5-hydro-deriv., reduction of the 4,5-double bond or by replacing R3 = H or R2 = H by R3 or R2 = alkyl, or by reduction of B=CO to B=CH2. Thus (I, B = CO, R3 = R4 = R5 = H, R6+R7 = bond and R1R2(COH)-1-hydroxy-ethyl) is prepd. by reducing the 7-acetyl deriv. with NaBH4. |
| format | Patent |
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(I):- (where B is CH2 or CO; R1, R2, R3 and R4 is H, or 1-7C alkyl; R5 is H or halogen; R6 and R7 are H or together a supplementary C-N-bond, are prepd. by cyclisation of the acetanilide, reduction of the 7-acyl cpds., oxidn. of the 4,5-hydro-deriv., reduction of the 4,5-double bond or by replacing R3 = H or R2 = H by R3 or R2 = alkyl, or by reduction of B=CO to B=CH2. Thus (I, B = CO, R3 = R4 = R5 = H, R6+R7 = bond and R1R2(COH)-1-hydroxy-ethyl) is prepd. by reducing the 7-acetyl deriv. with NaBH4.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1975</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19750730&DB=EPODOC&CC=PH&NR=9269A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19750730&DB=EPODOC&CC=PH&NR=9269A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YE FONG NING R</creatorcontrib><creatorcontrib>STERNBACH L</creatorcontrib><title>7-(HYDROXY LOWER ALKYL)BENZODIAZEPINE DERIVATIVES</title><description>Cpds. (I):- (where B is CH2 or CO; R1, R2, R3 and R4 is H, or 1-7C alkyl; R5 is H or halogen; R6 and R7 are H or together a supplementary C-N-bond, are prepd. by cyclisation of the acetanilide, reduction of the 7-acyl cpds., oxidn. of the 4,5-hydro-deriv., reduction of the 4,5-double bond or by replacing R3 = H or R2 = H by R3 or R2 = alkyl, or by reduction of B=CO to B=CH2. Thus (I, B = CO, R3 = R4 = R5 = H, R6+R7 = bond and R1R2(COH)-1-hydroxy-ethyl) is prepd. by reducing the 7-acetyl deriv. with NaBH4.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1975</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDA019XwiHQJ8o-IVPDxD3cNUnD08Y700XRy9Yvyd_F0jHIN8PRzVXBxDfIMcwzxDHMN5mFgTUvMKU7lhdLcDDJuriHOHrqpBfnxqcUFicmpeakl8QEelkZmlo7GBKQB_PAk3w</recordid><startdate>19750730</startdate><enddate>19750730</enddate><creator>YE FONG NING R</creator><creator>STERNBACH L</creator><scope>EVB</scope></search><sort><creationdate>19750730</creationdate><title>7-(HYDROXY LOWER ALKYL)BENZODIAZEPINE DERIVATIVES</title><author>YE FONG NING R ; STERNBACH L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PH9269A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1975</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>YE FONG NING R</creatorcontrib><creatorcontrib>STERNBACH L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YE FONG NING R</au><au>STERNBACH L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>7-(HYDROXY LOWER ALKYL)BENZODIAZEPINE DERIVATIVES</title><date>1975-07-30</date><risdate>1975</risdate><abstract>Cpds. (I):- (where B is CH2 or CO; R1, R2, R3 and R4 is H, or 1-7C alkyl; R5 is H or halogen; R6 and R7 are H or together a supplementary C-N-bond, are prepd. by cyclisation of the acetanilide, reduction of the 7-acyl cpds., oxidn. of the 4,5-hydro-deriv., reduction of the 4,5-double bond or by replacing R3 = H or R2 = H by R3 or R2 = alkyl, or by reduction of B=CO to B=CH2. Thus (I, B = CO, R3 = R4 = R5 = H, R6+R7 = bond and R1R2(COH)-1-hydroxy-ethyl) is prepd. by reducing the 7-acetyl deriv. with NaBH4.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | 7-(HYDROXY LOWER ALKYL)BENZODIAZEPINE DERIVATIVES |
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