Acetamide derivatives

The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effect...

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Bibliographische Detailangaben
Hauptverfasser: MORRIS, JEFFREY, JAMES, PRESTON JOHN, BRITTAIN, DAVID, ROBERT, COOPER, ANTHONY, LOREN, LONGRIDGE, JETHRO, LAURENCE, BROWN, STEVEN, PAUL, SLATER LINDA
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.