Tetrahydro-imidazolylmethyl carbazolones and analogs thereof for treating 5-ht function disturbances

Tetrahydro-imidazolylmethyl carbazolones and analogs thereof for treating 5-ht function disturbances

The invention relates to compounds of the general formula (I): (I) wherein Im represents an imidazolyl group of the formula: and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example,...

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Hauptverfasser: BELL JAMES ANGUS, BRADSHAW JOHN, EWAN GEORGE BLANCH, MITCHELL WILLIAM LEONARD, HUMBER DAVID CEDRIC, COATES IAN HAROLD
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator BELL JAMES ANGUS
BRADSHAW JOHN
EWAN GEORGE BLANCH
MITCHELL WILLIAM LEONARD
HUMBER DAVID CEDRIC
COATES IAN HAROLD
description The invention relates to compounds of the general formula (I): (I) wherein Im represents an imidazolyl group of the formula: and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Tetrahydro-imidazolylmethyl carbazolones and analogs thereof for treating 5-ht function disturbances
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