Tetrahydro-imidazolylmethyl carbazolones and analogs thereof for treating 5-ht function disturbances

The invention relates to compounds of the general formula (I): (I) wherein Im represents an imidazolyl group of the formula: and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example,...

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Bibliographische Detailangaben
Hauptverfasser:	BELL JAMES ANGUS, BRADSHAW JOHN, EWAN GEORGE BLANCH, MITCHELL WILLIAM LEONARD, HUMBER DAVID CEDRIC, COATES IAN HAROLD
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to compounds of the general formula (I): (I) wherein Im represents an imidazolyl group of the formula: and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.