PROCESS OF PRODUCING Sindora supa ANTI-DIABETES DRUG

The present utility model relates in general to a process of producing an herbal supplement for the prevention of diabetes mellitus. Specifically, it relates to the use of Sindora supa (S. supa) in producing a stable and standardized tablet dosage form of an anti-diabetes drug through alpha-glucosid...

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Hauptverfasser: ALTO, Philip Reginald C, YU, Raymond Fernando B, QUIBIN, Razile Kay A, DE LOS SANTOS, Mark Gabriel M, CATAP, Elena, AMOR, Evangeline C, BALOTRO, Bienvenido S, SANCHEZ, Arlyn C, BALANAY, Rua Marie F, REGUNTON, Precious Caree V, ALVARADO, Jowela B, VILLONES, Lareno Jr. L, JACINTO, Sonia, PEREDAS, Charmaine R, COTAS, Joyce Katherine P, FERNANDEZ, Patrick, YERRO, Jennylyn Z, NAVARRO, Anna Isabel, MORALES, John Perry C
Format: Patent
Sprache:eng
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Zusammenfassung:The present utility model relates in general to a process of producing an herbal supplement for the prevention of diabetes mellitus. Specifically, it relates to the use of Sindora supa (S. supa) in producing a stable and standardized tablet dosage form of an anti-diabetes drug through alpha-glucosidase inhibiting activity. The anti-diabetes drug composition comprises of: approximately 44-49 pcnt weight Sindora supa ethanolic extract; approximately 44-49 pcnt weight diluent preferably colloidal silica; approximately 1.78-1.96 pcnt weight disintegrant preferably crospovidone; approximately 4.44-4.90 pcnt binder preferably microcrystalline cellulose; and, approximately 0.45-0.49 pcnt flow activator preferably magnesium stearate. It is made by a process comprising: collecting and preparing raw materials; drying and milling the raw materials; subjecting the raw materials to ethanolic extraction; subjecting the ethanolic extract solution to rotary evaporation; subjecting the ethanolic extract to lyophilization; subjecting the ethanolic extract to quality control; conducting pre-formulation tests; dissolving the ethanolic extract in equal amounts of ethanol and colloidal silica; drying and sieving the silicated extract; mixing the silicated extract with microcrystalline cellulose, crospovidone, and magnesium stearate; subjecting the mixture to dry granulation; sieving and weighing the granular mixture; compressing the granular mixture into tablet dosage form; and, subjecting the tablets to quality control tests.