4-SUBSTITUTED THIAZOLYL-2-OXAMIC ACIDS AND SALTS AND ESTERS THEREOF

4-SUBSTITUTED THIAZOLYL-2-OXAMIC ACIDS AND SALTS AND ESTERS THEREOF

Compounds of the formula wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is hydrogen, methyl or carboxyl; and A is pyridyl, benzodioxanyl or where R3, R4 and R5, which may be identical to or different from each other, are each hydrogen, hydroxyl, alkoxy, alkyl, halogen, carboxyalkyl or ni...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PATRICK BRAIN STEWART, FRIEDRICH KARL HESS, JAMES THOMAS OLIVER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of the formula wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is hydrogen, methyl or carboxyl; and A is pyridyl, benzodioxanyl or where R3, R4 and R5, which may be identical to or different from each other, are each hydrogen, hydroxyl, alkoxy, alkyl, halogen, carboxyalkyl or nitro, or one of R3, R4 or R5 is dialkylamino, carboxamido, morpholino, piperidino, hydroxy-piperidino, cyano or phenyl; non-toxic salts thereof formed with an inorganic base when R1 is hydrogen and/or R2 is carboxyl; and non-toxic addition salts thereof formed with an organic base when R1 is hydrogen. The compounds are useful as antiallergics.