IMPROVED THYMIDINE KINASE GENE

Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic sys...

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Hauptverfasser: LEVY, John, P, JOHNSON, Robert, G, REED, Rebecca, A, MCNULTY, Joseph
Format: Patent
Sprache:eng
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Zusammenfassung:Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.