FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN, AND USE THEREOF

FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN, AND USE THEREOF

The present invention provides a fusion protein comprising an IL-2 protein and a CD80 protein. A fusion protein comprising a CD80 fragment, an immunoglobulin Fc, and an IL-2 variant, in one embodiment, can activate immune cells, such as natural killer cells, and, at the same time, can control the im...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: JANG, Myung Ho
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a fusion protein comprising an IL-2 protein and a CD80 protein. A fusion protein comprising a CD80 fragment, an immunoglobulin Fc, and an IL-2 variant, in one embodiment, can activate immune cells, such as natural killer cells, and, at the same time, can control the immune cell regulatory activity of regulatory T cells. Therefore, a pharmaceutical composition comprising the fusion protein as an active ingredient can increase the immune activity in vivo and can be effectively used for not only cancer but also infectious diseases, and thus is highly industrially applicable.