RNA MOLECULES

RNA MOLECULES

The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing. In one embodiment the dsRNA comprises a double hairpin (dumbbell) structure. In another embodiment a proportion of the sense and antisense strands of the dsRNA molecule contain ribonucleotide...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DORAN, Timothy James, GAO, Lingling, WANG, Ming-Bo, ALLU, Annapurna Devi, DE FEYTER, Robert, GREAVES, Ian Kevin, SMITH, Neil Andrew, TIZARD, Mark, ANDERSON, Jonathan Paul, ZHANG, Daai
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing. In one embodiment the dsRNA comprises a double hairpin (dumbbell) structure. In another embodiment a proportion of the sense and antisense strands of the dsRNA molecule contain ribonucleotides that are either basepaired in a non-canonical basepair or are not basepaired.