CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conj...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ZHAO, Robert Yongxin, LI, Wenjun, SU, Qingyu, GUO, Zhixiang, HUANG, Yuanyuan, YE, Zhicang, YANG, Qingliang, CAI, Xiang, ZUO, Xiaotao, TONG, Qianqian, ZHAO, Linyao, YE, Hangbo, PENG, Jie, GAI, Shun, YANG, Yanlei, XU, Jun, ZHU, Haifeng, JIA, Junxiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LIN, Chen, YANG, Chengyu, GAO, Shuihong, WANG, Chunyan, CHAO, Minjun, XIE, Hongsheng
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.