AN ORAL OSMOTIC PHARMACEUTICAL COMPOSITION OF VILDAGLIPTIN

AN ORAL OSMOTIC PHARMACEUTICAL COMPOSITION OF VILDAGLIPTIN

There is provided an osmotic pharmaceutical composition comprising: (a) a core, comprising: (i) a drug layer comprising vildagliptin or salt thereof, and one or more pharmaceutically acceptable excipients; (ii) a push layer comprising polyethylene oxide having molecular weight of about 5,000,000 to...

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Bibliographische Detailangaben
Hauptverfasser: GAIKWAD, Sanjay, SANGLE, Ganesh, SWAIN, Kapileshwar, AGARWAL, Sunil Kumar, BANSAL, Amit, KODGULE, Mandar Madhukar, SAIGAL, Nitin
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:There is provided an osmotic pharmaceutical composition comprising: (a) a core, comprising: (i) a drug layer comprising vildagliptin or salt thereof, and one or more pharmaceutically acceptable excipients; (ii) a push layer comprising polyethylene oxide having molecular weight of about 5,000,000 to about 8,000,000, wherein weight ratio of vildagliptin or salt thereof and polyethylene oxide ranges from about 1:1 to about 1:5; (b) a seal coat surrounding the core; (c) a sustained release coat cellulose acetate surrounding the seal coat; (d) an immediate release drug layer comprising vildagliptin or salt thereof surrounding the sustained release coat. Also provided is process of preparing such compositions.