RECOMBINANT ANTIBODIES HAVING DUAL SPECIFICITY FOR GANGLIOSIDES AND USE THEREOF

The present invention relates to novel monoclonal antibodies and fragments of said antibodies, which have dual specificity and a high affinity for the gangliosides N-acetyl GM3 and N-glicolyl GM3, and which do not recognize other gangliosides. According to another aspect, the present invention relates to the use of said antibodies and the fragments thereof in tumor therapy, in which said tumors have a significant expression of any of the two antigens recognized by said antibodies, or a mixed expression of both antigens. The invention also relates to a use of said antibodies in the diagnosis of tumors that express at least one of the antigens. (FR): La pr�sente invention concerne de nouveaux anticorps monoclonaux et des fragments de ces anticorps, � double sp�cificit� et affinit� �lev�e pour les gangliosides N-ac�tyl GM3 et N-glycolyle GM3, et qui ne reconnaissent pas d'autres gangliosides. Dans un autre aspect, la pr�sente invention concerne l'utilisation de ces anticorps et de leurs fragments dans le traitement de tumeurs qui poss�dent une expression significative de n'importe quel des deux antig�nes reconnus par ces anticorps, ou une expression mixte de ces antig�nes. Elle concerne �galement l'utilisation de ces anticorps dans le diagnostic de tumeurs qui expriment au moins un de ces antig�nes.