MODULADORES DE MONOACILGLICEROL LIPASA

Un compuesto de formula (I) donde R2 es pirazol, R3 es fenilo, R4 es alquilo. Composiciones farmaceuticas que los contienen, metodos para fabricarlos. Asi mismo, son utiles para tratar estados de enfermedad, trastornos y afecciones asociados con la modulacion de la MGL, tales como aquellos asociados con dolor, trastornos psiquiatricos, trastornos neurologicos. Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions.Wherein R1, R2, R2a, R3, R3a, R4, and R4a are defined herein.