DERIVADOS DE 2-PIRIDIN-2-IL-PIRAZOL-3(2H)-ONA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: X ES CH2, CH(R'), N(R'), O, S; R' ES UN GRUPO ALQUILO C1-C5, ALCOXI C1-C5, ENTRE OTROS; R1 ES OXO, COOH, W-OH, ENTRE OTROS; R2 ES H, ALQUILO C1-C5, ALCOXI C1-C5, COOH, ENTRE OTROS; W ES ALQUILENO C1-C5 OPCIONALMENTE SUSTITUIDO CON UNO O VARIOS GRUPOS HIDROXI; n ES 0-4; m ES 0-2; o ES 0-1. SON COMPUESTOS PREFERIDOS: N-ETIL-6-(3-OXO-1,3,4,5,6,7-HEXAHIDRO-2H-INDAZOL-2-IL)-N-FENILPIRIDINA-3-SULFONAMIDA; 6-(5-BENCIL-3-OXO-1,3,4,5,6,7-HEXAHIDRO-2H-PIRAZOLO[4,3-c]PIRIDIN-2-IL)-N,N-DIETILPIRIDINA-3-SULFONAMIDA; 2-{5-[ETIL(FENIL)SULFAMOIL]PIRIDON-2-IL}-3-OXO-1,2,3,4,6,7-HEXAHIDRO-5H-PIRAZOLO[4,3-c]PIRIDINA-5-CARBOXILATO DE METILO; ENTRE OTROS. REFERIDA TAMBIEN A UA FORMULACION FARMACEUTICA. DICHO COMPUESTO ES UN DERIVADO DE 2-PIRIDIN-2-IL-PIRAZOL-3(2H)-ONA UTIL COMO ACTIVADOR DEL FACTOR DE TRANSCRIPCION HIF The invention relates to compounds corresponding to formula (I), in the form of the base or of an acid-addition salt: in which n is equal to 0, 1, 2, 3 or 4; m is equal to 0, 1 or 2; o is equal to 0 or 1; X represents a group -CH2, -CH(R′)-, -NH(R′)- or a heteroatom chosen from O and S, it being understood that R′ represents a group -(C1-C5)alkyl, -(C1-C5)alkoxy, -CH2-aryl, -C(O)R5 or -COOR5; R1 represents an oxo group, -COOR5, -W-OH or -W-NR5R6; R2 represents an H atom or a group chosen from the groups (i) -(C1-C5)alkyl, (ii) -(C1-C5)alkoxy, (iii) -COOR5, (iv) -NR5R6, (v) -C(O)-NR5R6, (vi) -SO2-NR3R4, (vii) heteroaryl optionally substituted with a group -(C1-C5)alkyl, (viii) -W-aryl, (ix) -W-heteroaryl, (x) -O-W-aryl, (xi) -O-W-heteroaryl and (xii) -O-W-NR5R6; it being understood that R3 and R4, (i) which may be identical or different, represent, independently of each other, an H atom, a group -(C1-C5)alkyl, -(C3-C6)cycloalkyl, aryl, heteroaryl, -CH2-heteroaryl, -(C1-C5)alkyl-NR5R6, -W-OH or -W-NR5R6; or (ii) form, together with the nitrogen atom that bears them, a heterocycloalkyl group optionally substituted with one or more groups chosen from the groups -(C1-C5)alkyl and -CH2-aryl; W is a group -(C1-C5)alkylene, optionally substituted with one or more hydroxyl groups; R5 and R6, which may be identical or different, represent, independently of each other, a hydrogen atom or a group chosen from the groups -(C1-C5)alkyl and the groups -(C3-C6)cycloalkyl, and also the process for preparing them and the therapeutic uses thereof.