DERIVADOS DE PIRIDIN-IL-OXI-PIRIDINAS COMO INHIBIDORES DE ALK5

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HALO, NITRO, CIANO, SULFO, ENTRE OTROS; R3 ES HALO, NITRO, CIANO, SULFO, HIDROXI, ENTRE OTROS; R2 ES H, HALO, CIANO, MERCAPTO, ENTRE OTROS; n ES 0-3; A ES ANILLO CARBOCICLICO, HETEROCICLICO SUSTIUIDOS O NO POR HALO, CIANO, NITRO, HIDROXI, ENTRE OT...

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Hauptverfasser:	RUDGE DAVID ALAN, FINLAY MAURICE RAYMOND VERSCHOYLE, ROBERTS NICOLA JANE, ROBERTS CRAIG ANTHONY, GOLDBERG FREDERICK WOOLF
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HALO, NITRO, CIANO, SULFO, ENTRE OTROS; R3 ES HALO, NITRO, CIANO, SULFO, HIDROXI, ENTRE OTROS; R2 ES H, HALO, CIANO, MERCAPTO, ENTRE OTROS; n ES 0-3; A ES ANILLO CARBOCICLICO, HETEROCICLICO SUSTIUIDOS O NO POR HALO, CIANO, NITRO, HIDROXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(5,6-DIMETIL-2-PIRIDIN-2-IL-PIRIDIN-3-IL)OXI-N-PIRIDIN-2-IL-PIRIDIN-2-AMINA; N-(2-AMINO-2-OXOETIL)-3-{[4-(2,6-DIMETILPIRIDIN-3-IL)-OXIPIRIDIN-2-IL]AMINO}BENZAMIDA; 4-(2,6-DIMETIL-PIRIDIN-3-IL)OXI-N-{3-[(4-METILSULFONIL-PIPERAZIN-1-IL)METIL]FENIL}PIRIDIN-2-AMINA; ENTRE OTROS.DICHOS COMPUESTOS SON INHIBIDORES DE ALK5 UTILES EN EL TRATAMIENTO DE CANCER The invention relates to chemical compounds of the formula (I), or pharmaceutically acceptable salts thereof, which possess ALK5 (TGFbetaR1) inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal such as man.