SULFAMATOS DE 2-ALCOXIESTRADIOL DE ACCION ANTITUMORAL

SE REFIERE AL USO DE SULFAMATOS 2-ALCOXIESTRADIOL DE FORMULA I DONDE R1 Y R2 SON H, METILO, ACILO C1-C4, BENCILO; R3 ES ALQUILO C1-C4, CnFmHo; n ES 1-6; m MAYOR 1 Y m+O ES 2n+1; R4 Y R5 SON H, O JUNTOS SON METILENO, UNION ADICIONAL; R6 ES H; R7 ES OH, ALQUILO C1-C4, O-ACILO C1-C11, OSO2NR1R2; PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES TUMORALES INFLUIDAS POSITIVAMENTE POR INHIBICION DE POLIMERASA DE TUBULINA, ENFERMEDADES TUMORALES DE GLANDULAS Y ORGANOS SEXUALES MASCULINOS Y FEMENINOS, CARCINOMA DE MAMAS. TAMBIEN SE REFIERE A LOS COMPUESTOS 2-METOXI-17ß-HIDROXI-ESTRA-1,3,5(10)-TRIEN-3-IL-SULFAMATO, 2-METOXI-17O-HIDROXI-ESTRA-1,3,5(10)-TRIEN-3-IL-SULFAMATO, 2-METOXI-17ß-HIDROXI-ESTRA-1,3,5(10)-TRIEN-3-IL-N-ACETILSULFAMATO, 2-METOXI-17O-HIDROXI-14O,15O-METILEN-ESTRA-1,3,5(10)-TRIEN-3-IL-TRIEN-3-IL-ACETILSULFAMATO, 2-METOXI-17O-HIDROXI-14O,15O-METILEN-ESTRA-1,3,5(10)-TRIEN-3-IL-SULFAMATO; ENTRE OTROS The invention relates to the use of 2-alkoxyestrogen sulfamates of general formula (I) for producing a medicament for the treatment of tumorous diseases, which are positively influenced by the inhibition of tubulin polymerisation. In said formula, R and R independently of one another represent H, methyl, C1-C4 acyl or benzyl, R represents C1-C4 alkyl, or a group of formula CnFmHo, where n = 1, 2, 3, 4, 5 or 6, m > 1 and m + o = 2n + 1, R and R independently represent H, or together represent a methylene group or an additional bond, R represents H and R represents OH, OC1-C4 alkyl, OC1-C11 acyl or OSO2NR R , whereby in the B and C ring of the steroid skeleton the broken lines can additionally represent up to two double bonds. The inventive compounds are characterised by a 2-alkoxy substitution in conjunction with a 17-hydroxy substitution. They exhibit the specific activity of inhibiting tubulin polymerisation and can be used, for example, for treating prostatic carcinoma.