FORMULACIONES DE INTERFERON ß HUMANO
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONSISTE ESENCIALMENTE DE: i)0,25mg/ml A 25mg/ml DE INTERFERON ß IFNß-1b BIOLOGICAMENTE ACTIVO NO GLICOSILADO QUE SE PRODUCE EN UN HUESPED BACTERIANO; ii)AMORTIGUADOR QUE CONTIENE DE 1mM A 100mM DE GLICINA, HCl; iii)AGUA, ESTERIL; CARACTERIZADA POR pH DE...
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| creator | MCCAMAN MICHAEL PUNGOR ERNO OTTOBONI SUSANNE |
| description | SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONSISTE ESENCIALMENTE DE: i)0,25mg/ml A 25mg/ml DE INTERFERON ß IFNß-1b BIOLOGICAMENTE ACTIVO NO GLICOSILADO QUE SE PRODUCE EN UN HUESPED BACTERIANO; ii)AMORTIGUADOR QUE CONTIENE DE 1mM A 100mM DE GLICINA, HCl; iii)AGUA, ESTERIL; CARACTERIZADA POR pH DE 2 A 4, ESTAR LIBRE DE ESTABILIZADORES CONVENCIONALES COMO ALBUMINA DE SUERO, NO CONTENER UNA CANTIDAD DETECTABLE DE SOLUBILIZADORES TAL COMO DETERGENTE. EL IFNß PUEDE SER UTIL PARA EL TRATAMIENTO DE ESCLEROSIS MULTIPLE
The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN-beta lyophilizates prepared from biologically active IFN-beta, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. |
| format | Patent |
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The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN-beta lyophilizates prepared from biologically active IFN-beta, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0.</description><edition>7</edition><language>spa</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030621&DB=EPODOC&CC=PE&NR=20030303A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030621&DB=EPODOC&CC=PE&NR=20030303A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MCCAMAN MICHAEL</creatorcontrib><creatorcontrib>PUNGOR ERNO</creatorcontrib><creatorcontrib>OTTOBONI SUSANNE</creatorcontrib><title>FORMULACIONES DE INTERFERON ß HUMANO</title><description>SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONSISTE ESENCIALMENTE DE: i)0,25mg/ml A 25mg/ml DE INTERFERON ß IFNß-1b BIOLOGICAMENTE ACTIVO NO GLICOSILADO QUE SE PRODUCE EN UN HUESPED BACTERIANO; ii)AMORTIGUADOR QUE CONTIENE DE 1mM A 100mM DE GLICINA, HCl; iii)AGUA, ESTERIL; CARACTERIZADA POR pH DE 2 A 4, ESTAR LIBRE DE ESTABILIZADORES CONVENCIONALES COMO ALBUMINA DE SUERO, NO CONTENER UNA CANTIDAD DETECTABLE DE SOLUBILIZADORES TAL COMO DETERGENTE. EL IFNß PUEDE SER UTIL PARA EL TRATAMIENTO DE ESCLEROSIS MULTIPLE
The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN-beta lyophilizates prepared from biologically active IFN-beta, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB18w_yDfVxdPb093MNVnBxVfD0C3ENcnMN8vdTODxfwSPU19HPn4eBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxAe4GhkYGIOgo6ExMWoA7Q8j8g</recordid><startdate>20030621</startdate><enddate>20030621</enddate><creator>MCCAMAN MICHAEL</creator><creator>PUNGOR ERNO</creator><creator>OTTOBONI SUSANNE</creator><scope>EVB</scope></search><sort><creationdate>20030621</creationdate><title>FORMULACIONES DE INTERFERON ß HUMANO</title><author>MCCAMAN MICHAEL ; PUNGOR ERNO ; OTTOBONI SUSANNE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PE20030303A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2003</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MCCAMAN MICHAEL</creatorcontrib><creatorcontrib>PUNGOR ERNO</creatorcontrib><creatorcontrib>OTTOBONI SUSANNE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MCCAMAN MICHAEL</au><au>PUNGOR ERNO</au><au>OTTOBONI SUSANNE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FORMULACIONES DE INTERFERON ß HUMANO</title><date>2003-06-21</date><risdate>2003</risdate><abstract>SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONSISTE ESENCIALMENTE DE: i)0,25mg/ml A 25mg/ml DE INTERFERON ß IFNß-1b BIOLOGICAMENTE ACTIVO NO GLICOSILADO QUE SE PRODUCE EN UN HUESPED BACTERIANO; ii)AMORTIGUADOR QUE CONTIENE DE 1mM A 100mM DE GLICINA, HCl; iii)AGUA, ESTERIL; CARACTERIZADA POR pH DE 2 A 4, ESTAR LIBRE DE ESTABILIZADORES CONVENCIONALES COMO ALBUMINA DE SUERO, NO CONTENER UNA CANTIDAD DETECTABLE DE SOLUBILIZADORES TAL COMO DETERGENTE. EL IFNß PUEDE SER UTIL PARA EL TRATAMIENTO DE ESCLEROSIS MULTIPLE
The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN-beta lyophilizates prepared from biologically active IFN-beta, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FORMULACIONES DE INTERFERON ß HUMANO |
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