Substituted benzopyran analogs for the treatment of inflammation

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as de...

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Hauptverfasser:	OBUKOWICZ, MARK, G, HANAU, CATHLEEN, E, BROWN, DAVID, L, CARTER, JEFFREY, S, SRINIVASAN NAGARAJAN, LUDWIG, CINDY, L, SUZANNE METZ, HARTMANN, SUSAN, J, BALEKUDRU DEVADAS, GRANETO, MATTHEW, J, KORTE, DONALD, E, BERTENSHAW, STEPHEN, R, ROGIER, DONALD, J., JR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.