Substituted benzopyran derivatives for the treatment of inflammation

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.

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Hauptverfasser: OBUKOWICZ, MARK, G, NAGARAJAN, SRINIVASAN, R, TALLEY, JOHN, J, HANAU, CATHLEEN, E, BROWN, DAVID, L, CARTER, JEFFREY, S, CARTER, S. JEFFREY, LUDWIG, CINDY, L, SUZANNE METZ, HARTMANN, SUSAN, J, GRANETO, MATTHEW, J, BALEKUDRU DEVADAS, BERTENSHAW, STEPHEN, R, ROGIER, DONALD, J., JR
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creator OBUKOWICZ, MARK, G
NAGARAJAN, SRINIVASAN, R
TALLEY, JOHN, J
HANAU, CATHLEEN, E
BROWN, DAVID, L
CARTER, JEFFREY, S
CARTER, S. JEFFREY
LUDWIG, CINDY, L
SUZANNE METZ
HARTMANN, SUSAN, J
GRANETO, MATTHEW, J
BALEKUDRU DEVADAS
BERTENSHAW, STEPHEN, R
ROGIER, DONALD, J., JR
description A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Substituted benzopyran derivatives for the treatment of inflammation
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