Method for culturing cord blood-derived natural killer cells using transformed t-cells

Method for culturing cord blood-derived natural killer cells using transformed t-cells

The present invention pertains to a method for culturing cord blood-derived natural killer cells using transformed T-cells expressing 4-1 BBL, mbIL-21, OX40L or mTNF-α, or a combination thereof. The method for culturing natural killer cells using transformed T-cells according to the present inventio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Eun Ji, Kim, You-Sun, Cho, Sung Yoo, Park, Gyeong Min, Min, Bokyung, Hwang, Yu Kyeong, Yang, Bitna
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention pertains to a method for culturing cord blood-derived natural killer cells using transformed T-cells expressing 4-1 BBL, mbIL-21, OX40L or mTNF-α, or a combination thereof. The method for culturing natural killer cells using transformed T-cells according to the present invention can effectively propagate and produce natural killer cells from a small amount of raw cells. In addition, the method can also improve the cell-killing ability of natural killer cells. Thus, the method for culturing natural killer cells using transformed T-cells according to the present invention can be usefully used to commercialize cell therapeutic agents. Moreover, natural killer cells produced by the culturing method of the present invention can be usefully used as a cell therapeutic agent.