Methods and compositions for reducing the immunogenicity of chimeric notch receptors
The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, which can be genetically engineered in cells of the monocyte/macrophage lineage for drug delivery. Specifically, the invention relates to transcription factors useful for controllin...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, which can be genetically engineered in cells of the monocyte/macrophage lineage for drug delivery. Specifically, the invention relates to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors. The transcriptional regulator comprises a DNA binding domain of human origin and a transactivation domain of human origin. |
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