Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I), where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

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Bibliographische Detailangaben
Hauptverfasser:	Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia, Jr, Wang, Zhongguo, Diebold, R. Bruce
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I), where A, U, W1, W2, W3, R1-R6, and R9 are described herein.