Anti-n3pglu amyloid beta peptide antibodies and uses thereof

Antibodies to human N3pGlu Aβ and compositions comprising such N3pGlu Aβ antibodies, which are suitable for the treatment of a disease characterized by deposition of Aβ including clinical or pre-clinical Alzheimers disease, Downs syndrome, and clinical or pre-clinical cerebral amyloid angiopathy. Th...

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Bibliographische Detailangaben
Hauptverfasser:	Lu, Jirong, Demattos, Ronald Bradley, Tang, Ying
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Antibodies to human N3pGlu Aβ and compositions comprising such N3pGlu Aβ antibodies, which are suitable for the treatment of a disease characterized by deposition of Aβ including clinical or pre-clinical Alzheimers disease, Downs syndrome, and clinical or pre-clinical cerebral amyloid angiopathy. The antibodies claimed have reduced immunogenicity over existing anti-N3pGlu Aβ in the art.