Apparatus and methods for sealing a vascular puncture

The present invention seeks to reduce time and risk to vessel injury and infection involved in sheath exchange between an introducer sheath used during a diagnostic or therapeutic procedure and a sheath that is compatible with the closure system. This is achieved by providing a closure system that is compatible with a standard procedural sheath and that integrates the standard procedural sheath into a sealant delivery method. The present invention provides a closure system for use with a procedural sheath used in performing an arteriotomy, the procedural sheath having a side port, the closure system comprising: a handle portion; an outer catheter extending distally from the handle portion, the outer catheter comprising a proximal section and a distal section; an inner catheter extending through the outer catheter and removably secured thereto, the outer catheter axially movable with respect to the inner catheter; a sealant positioned in the distal section of the outer catheter; and a support tube positioned proximal to the sealant and radially between the outer catheter and the inner catheter; wherein the handle portion comprises a sheath adapter extending therefrom, the sheath adapter comprising an attachment structure defining a passageway, and wherein the sheath adapter is releasably secured to the procedural sheath by positioning the side port of the procedural sheath into the passageway of the attachment structure.