Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
Provided herein are KRAS G12C inhibitors, compositions of the same and methods of using the same. In particular, the present invention provides compounds having the general structure of formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables of Formula (II) are defined here...
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Zusammenfassung: | Provided herein are KRAS G12C inhibitors, compositions of the same and methods of using the same. In particular, the present invention provides compounds having the general structure of formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables of Formula (II) are defined herein. These compounds are useful for treating a number of disorders, including pancreatic, colorectal and lung cancers. |
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