Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer

Provided herein are KRAS G12C inhibitors, compositions of the same and methods of using the same. In particular, the present invention provides compounds having the general structure of formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables of Formula (II) are defined here...

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Bibliographische Detailangaben
Hauptverfasser: Ashton, Kate, Lanman, Brian Alan, Yang, Kevin C, Pickrell, Alexander J, Booker, Shon, Tegley, Christopher M, Cee, Victor J, Lopez, Patricia, Reed, Anthony B, Wang, Hui-Ling, Kopecky, David John
Format: Patent
Sprache:eng
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Zusammenfassung:Provided herein are KRAS G12C inhibitors, compositions of the same and methods of using the same. In particular, the present invention provides compounds having the general structure of formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables of Formula (II) are defined herein. These compounds are useful for treating a number of disorders, including pancreatic, colorectal and lung cancers.