Heteroarylphenoxy benzamide kappa opioid ligands

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compound s or...

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Bibliographische Detailangaben
Hauptverfasser: Verhoest, Patrick Robert, Kauffman, Gregory Wayne, Mente, Scot, Brodney, Michael Aaron, Arora, Kapildev Kashmirilal, Rogers, Bruce Nelsen, Dunn, Matthew Francis, Kablaoui, Natasha Mariam, Rankic, Danica Antonia, Montgomery, Justin Ian, Green, Michael Eric
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compound s or s al ts, an d thei r uses for treating kappa opioid (κ-opioid) associated disorders including, e.g., a neurological disorder, or psychiatric disorder such as a neurocognitive disorder, substance abuse disorder, depressive disorder, anxiety disorder, trauma and stressor related disorder and feeding and eating disorder.