Anti-pd-1 antibodies, method for producing same and method for using same

The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fra...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Ekimova, Viktoriia Mikhailovna, Korzhavin, Dmitry Valeryevich, Vladimirova, Anna Konstantinovna, Ivanov, Roman Alekseevich, Diduk, Sergei Vasilyevich, Artiukhova, Marina Vladimirovna, Goncharova, Olga Vladimirovna, Ulitin, Andrei Borisovich, Solovyev, Valery Vladimirovich, Ustiugov, Iakov Iurevich, Bulankina, Irina Andreevna, Eroshova, Anna Vladimirovna, Nemankin, Timofey Aleksandrovich, Chernykh, Yulia Sergeevna, Morozov, Dmitry Valentinovich
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases related to various disorders of cell proliferation and development. The invention also relates to methods for producing the indicated antibodies, and to a method for treating human diseases using said antibodies.