Nitroxyl donors with improved therapeutic index

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds of formula (3), pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of u...

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Bibliographische Detailangaben
Hauptverfasser:	Toscano, John, Brookfield, Frederick Arthur, Frost, Lisa Marie, Kalish, Vincent Jacob, Courtney, Stephen Martin
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosed subject matter provides N-substituted hydroxylamine derivative compounds of formula (3), pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.