Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof

There is a need to develop alternative long-acting injectable composition comprising an isoxazoline compound. Accordingly, the present disclosure provides a long-acting injectable composition, comprising at least one parasiticidal isoxazoline active agent of formula (Ic), or a pharmaceutically accep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Cheifetz, Peter, Meng, Charles, Le Hir De Fallois, Lois, Cady, Susan, Galeska, Izabela
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:There is a need to develop alternative long-acting injectable composition comprising an isoxazoline compound. Accordingly, the present disclosure provides a long-acting injectable composition, comprising at least one parasiticidal isoxazoline active agent of formula (Ic), or a pharmaceutically acceptable salt thereof, wherein X1, X2 and X3 are defined herein, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This disclosure also provides isoxazoline active agents with long-lasting efficacy against ectoparasites. This disclosure also provides for methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering isoxazoline compounds and long-acting injectable compositions of the disclosure to the animal in need thereof.