Antiparasitic isoxazoline compounds, long-acting injectable formulations comprising them, methods and uses thereof
There is a need to develop alternative long-acting injectable composition comprising an isoxazoline compound. Accordingly, the present disclosure provides a long-acting injectable composition, comprising at least one parasiticidal isoxazoline active agent of formula (Ic), or a pharmaceutically accep...
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Zusammenfassung: | There is a need to develop alternative long-acting injectable composition comprising an isoxazoline compound. Accordingly, the present disclosure provides a long-acting injectable composition, comprising at least one parasiticidal isoxazoline active agent of formula (Ic), or a pharmaceutically acceptable salt thereof, wherein X1, X2 and X3 are defined herein, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This disclosure also provides isoxazoline active agents with long-lasting efficacy against ectoparasites. This disclosure also provides for methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering isoxazoline compounds and long-acting injectable compositions of the disclosure to the animal in need thereof. |
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