Anti-cd43 antibody and use thereof for cancer treatment

The present invention relates to an antibody for cancer treatment and provides an anti-CD43 antibody which binds an extracellular region of CD43 consisting of 6-9 amino acids in the amino acid sequence EGSPLWTSI, an anti-cancer composition and a composition for inhibiting cancer stem cells comprisin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Yoon, Sangsoon, Koukoulas, Irene, Hong, Kwon Pyo, Wilson Jr, David S, Cristiano, Briony, Kopsidas, George, Vincent Batori
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to an antibody for cancer treatment and provides an anti-CD43 antibody which binds an extracellular region of CD43 consisting of 6-9 amino acids in the amino acid sequence EGSPLWTSI, an anti-cancer composition and a composition for inhibiting cancer stem cells comprising the anti-CD43 antibody as an active ingredient, and a method for screening a cancer stem cell inhibitor. The anti-CD43 antibody comprises: heavy chain CDRs according to GYXMN (wherein X is F or Y), RINPNXGDSFYNQKFXG (wherein the first X is N or S; and the second X is Q or K), and EGYYGGRGYALDY; and light chain CDRs according to RTSQDISNYLN, XTXRLHS (wherein the first X is N, Q or A; and the second X is S or A), and QQSNMFPY.