Novel compounds as ror gamma modulators

Novel compounds as ror gamma modulators

Described are specific compounds of formula (I) and pharmaceutically acceptable salts thereof, which are active as modulators of retinoid-related orphan receptor gamma. Representative compounds include 2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl)acetamide, N...

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Hauptverfasser: Khairatkar-Joshi, Neelima, Harde, Rajendra Laxman, Pardeshi, Shailesh Ramesh, Bajpai, Malini, Gharat, Laxmikant Atmaram, Thomas, Abraham, Shelke, Sandeep Yadunath, Shah, Daisy Manish, Das, Sanjib
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Described are specific compounds of formula (I) and pharmaceutically acceptable salts thereof, which are active as modulators of retinoid-related orphan receptor gamma. Representative compounds include 2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl)acetamide, N-(4-(3-(4-chlorophenyl)pyrazin-2-yl)phenyl)-2-(4-(1,1-difluoro-2- methoxyethyl)phenyl)acetamide and (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl)acetamide. These compounds are therefore useful in the treatment of rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease (COPD), asthma, multiple sclerosis, colitis, ulcerative colitis and inflammatory bowel disease.