Synthesis of polycyclic-carbamoylpyridone compounds

Synthesis of polycyclic-carbamoylpyridone compounds

A synthetic method for preparing polycyclic-carbamoylpyridone compounds of Formula I where the bridged ring system is formed prior to a final hydroxyl deprotection step. A synthesis of Bictegravir is exemplified.

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Bibliographische Detailangaben
Hauptverfasser: Trinidad, Jonathan, Ikemoto, Norihiro, Griggs, Nolan, Keaton, Katie, Enquist, John, Schrier, Kate, Chiu, Anna, Peng, Zhihui, Herpt, Jochem, Hale, Christopher, Leeman, Michel, Kraft, Matt, Lazerwith, Scott, Waltman, Andrew
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A synthetic method for preparing polycyclic-carbamoylpyridone compounds of Formula I where the bridged ring system is formed prior to a final hydroxyl deprotection step. A synthesis of Bictegravir is exemplified.