Compositions for inhibiting masp-2 dependent complement activation

An isolated monoclonal antibody, or antigen-binding fragment thereof, that binds to human MASP-2, comprising a heavy chain variable region comprising the amino acid sequences set forth as amino acid residues 1 to 120 of SEQ ID NO:56, and a light chain variable region comprising the amino acid sequen...

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Bibliographische Detailangaben
Hauptverfasser:	Reiersen, Herald, Parent, James, Tedford, Clark, Kiprijanov, Sergej, Dudler, Thomas, Kavlie, Anita, Gombotz, Wayne, Hagemann, Urs
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An isolated monoclonal antibody, or antigen-binding fragment thereof, that binds to human MASP-2, comprising a heavy chain variable region comprising the amino acid sequences set forth as amino acid residues 1 to 120 of SEQ ID NO:56, and a light chain variable region comprising the amino acid sequences set forth as amino acid residues 146 to 250 of SEQ ID NO:56.