Selective bace1 inhibitors

Selective bace1 inhibitors

The present invention provides a compound of Formula II or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of BACE and can be selective inhibitors of BACE1 over BACE2. The compounds can be useful for treating Alzheimer's disease or for preventing the progression of mild...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Richards, Simon James, Winneroski, Leonard Larry, Mcmahon, Jennifer Anne, Woods, Timothy Andrew, Lopez, Jose Eduardo, Hembre, Erik James
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a compound of Formula II or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of BACE and can be selective inhibitors of BACE1 over BACE2. The compounds can be useful for treating Alzheimer's disease or for preventing the progression of mild cognitive impairment to Alzheimer's disease.