Multivalent ligand-lipid constructs

Multivalent ligand-lipid constructs are disclosed. The lipidated tetraantennary constructs are dispersible in water, yet readily and spontaneously incorporate into the membranes of cells. Embodiments of the constructs are demonstrated to promote improved rates of complement mediated lysis of cells.

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Bibliographische Detailangaben
Hauptverfasser:	Bovin, Nicolai Vladimirovich, Rodionov, Igor Leonidovich, Tuzikov, Alexander Borisovich, Henry, Stephen Micheal, Korchagina, Elena
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	Multivalent ligand-lipid constructs are disclosed. The lipidated tetraantennary constructs are dispersible in water, yet readily and spontaneously incorporate into the membranes of cells. Embodiments of the constructs are demonstrated to promote improved rates of complement mediated lysis of cells.