Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Shuichan, Hansen, Joshua, Schwarz, Kimberly, Hubbard, Robert, Torres, Eduardo, Huang, Dehua, Raheja, Raj, Bahmanyar, Sogole, Sloss, Marianne, Moghaddam, Mehran, Alexander, Matthew, Raymon, Heather, Zhao, Jingjing, Leisten, Jim, Tran, Tam, Jeffy, Brandon, Boylan, John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having the following formula (I) and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2 and R3 are as defined herein.