Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof

Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula (I) structure and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Al...

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Bibliographische Detailangaben
Hauptverfasser: Ray, Nicholas Charles, Zbieg, Jason, Lai, Kwong Wah, Wang, Tao, Wai, John Sui-Man, Labadie, Sharada, Liao, Jiangpeng, Liang, Jun, Liu, Zhiguo, Wang, Xiaojing, Zhang, Birong, Goodacre, Simon Charles, Ortwine, Daniel Fred, Li, Jun
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula (I) structure and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.