Factor viii formulation

Factor viii formulation

The invention relates to aqueous compositions of factor VIII (FVIII) and their use. Said compositions contain a FVIII molecule, 40 to 195 mM of a sodium salt, histidine, at least 1 mM of a calcium salt, and a surfactant; The concentration of histidine and calcium are inversely related to each other,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bodenbender, Christina, Metzner, Hubert, Liebing, Uwe
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to aqueous compositions of factor VIII (FVIII) and their use. Said compositions contain a FVIII molecule, 40 to 195 mM of a sodium salt, histidine, at least 1 mM of a calcium salt, and a surfactant; The concentration of histidine and calcium are inversely related to each other, such that the concentration of histidine is equal to or greater than 180 mM minus 20-times the concentration of calcium ions ([His] ≥180 mM - 20*[Ca2+]).