A high cell density fill and draw fermentation process

A high cell density fill and draw fermentation process

The present invention relates to a high cell density fermentation fill and draw process for producing a product in a bioreactor system wherein during the fermentation, medium comprising impurities is removed via an impurity filter unit while new fresh medium is added to the cell culture vessel to re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Laustsen, Mads
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to a high cell density fermentation fill and draw process for producing a product in a bioreactor system wherein during the fermentation, medium comprising impurities is removed via an impurity filter unit while new fresh medium is added to the cell culture vessel to replenish consumed nutrients and expelled medium. The addition of fresh medium and elimination of impurities provides the cells with the optimal environment to achieve high cell concentrations and thus higher productivity