Process for manufacturing pyrimidine sulfamide derivatives

Process for manufacturing pyrimidine sulfamide derivatives

The invention relates to a process for manufacturing the compound of formula I wherein R is H, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is H, or a salt thereof, in th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Funel, Jacques-Alexis, Schindelholz, Ivan, Abele, Stefan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a process for manufacturing the compound of formula I wherein R is H, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is H, or a salt thereof, in the presence of a base, and, when X is Br or Cl, in the presence of tetra-n-butyl ammonium fluoride hydrate or cesium fluoride with higher purity and yield. The invention further relates to the compound of formula I-1 and uses thereof.