Means and methods for producing stable antibodies

The present invention provides methods for obtaining, from an ex vivo B cell culture, B cells that are capable of producing antibodies with a higher stability and with the same or a lower binding affinity, as compared to an initial parent antibody. These B cells are obtained by selecting B cells wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bakker, Adrianus Quirinus, Kwakkenbos, Mark Jeroen, Wagner, Koen
Format: Patent
Sprache:eng
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