Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

Production method for 2-fluoro-4-borono-l-phenylalanine, and precursor of 2-fluoro-4-borono-l-phenylalanine

The present invention involves preparing phenylalanine derivatives, wherein the -para position of the phenylalanine side chain is substituted with a chloro, bromo, or iodo group, and the -ortho position is substituted with an excellent leaving group or a direct synthetic intermediate. These phenylal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nakashima, hideki, Kirihata, mitsunori, Ohta, yoichiro, Taguchi, yusuke, Uehara, kohki, Ishino, yuko, Takenaka, hiroshi, Yoshikawa, tomohiro, Ueda, sayuri
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention involves preparing phenylalanine derivatives, wherein the -para position of the phenylalanine side chain is substituted with a chloro, bromo, or iodo group, and the -ortho position is substituted with an excellent leaving group or a direct synthetic intermediate. These phenylalanine derivatives can be used in a method to efficiently introduce 18F- into the molecule during the later steps in a synthetic scheme.