Synthetic route to 2'-deoxy-2',2'-difluorotetrahydrouridines

The present invention relates to a method of producing compound 1, or a salt thereof; comprising precipitating or crystallizing compound 1 from a solution of compound 2, in the presence of a catalyst, wherein the catalyst is 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU), acetic acid, trifluoroacetic acid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Mathieu, Steven, Lewis, Bryan Matthew, Choi, Hyeong-Wook, Fang, Frank
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to a method of producing compound 1, or a salt thereof; comprising precipitating or crystallizing compound 1 from a solution of compound 2, in the presence of a catalyst, wherein the catalyst is 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU), acetic acid, trifluoroacetic acid, diisopropylethylamine, or ammonium hydroxide.