Solid forms of ceftolozane

Provided are solid forms of ceftolozane sulfate. Ceftolozane is also known as ((6R,7R)-3-[(5-amino-4-{ [(2-aminoethyl)carbamoyl]amino} -1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-({ (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl} amino)-8-oxo-5-thia-1-azabicyclo[4.2.0...

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Bibliographische Detailangaben
Hauptverfasser:	Kristos Adrian Moshos, You Seok Hwang, Joseph Terracciano, Asli Ovat, Nicole Miller Damour, Lisa Duong, Valdas Jurkauskas, Jason Woertink, Sanjay Mudur
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are solid forms of ceftolozane sulfate. Ceftolozane is also known as ((6R,7R)-3-[(5-amino-4-{ [(2-aminoethyl)carbamoyl]amino} -1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-({ (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl} amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate). Form 1 has diffractions at angles (2 theta ±0.2) of 12.4, 16.4, 22.6, 25.1, and 28.0. Form 2 has diffractions at angles (2 theta ±0.2) of 4.4, 8.8, 11.0, 14.9, and 17.7. Additionally provided are pharmaceutical compositions comprising the solid forms, and prepared by lyophilising the solid forms. The pharmaceutical compositions can additionally contain tazobactam. Ceftolozane is an antibacterial agent.