Oil-based adjuvants

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compo...

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Hauptverfasser: Mahan Suman, Mohr Kaori, Krebs Richard Lee, Jaglarz Anita Dorota, Lightle Sandra Ann Marie, Fontaine Michael Christopher, Dominowski Paul Joseph, Fitzpatrick Julie Lydia, Gallo Guillermo, Hardham John Morgan, Wilmes Lauren, Salmon Sarah A, Rai Sharath K, Foss Dennis L, Donachie William, Mwangi Duncan, Vora Shaunak, Mediratta Sangita, Smith David George Emslie
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creator Mahan Suman
Mohr Kaori
Krebs Richard Lee
Jaglarz Anita Dorota
Lightle Sandra Ann Marie
Fontaine Michael Christopher
Dominowski Paul Joseph
Fitzpatrick Julie Lydia
Gallo Guillermo
Hardham John Morgan
Wilmes Lauren
Salmon Sarah A
Rai Sharath K
Foss Dennis L
Donachie William
Mwangi Duncan
Vora Shaunak
Mediratta Sangita
Smith David George Emslie
description The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals. More specifically, the present invention provides oil emulsions with at least 50 % (v/v) oily phase that may be used with antigens to form vaccine compositions.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Oil-based adjuvants
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