Oil-based adjuvants

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Mahan Suman, Mohr Kaori, Krebs Richard Lee, Jaglarz Anita Dorota, Lightle Sandra Ann Marie, Fontaine Michael Christopher, Dominowski Paul Joseph, Fitzpatrick Julie Lydia, Gallo Guillermo, Hardham John Morgan, Wilmes Lauren, Salmon Sarah A, Rai Sharath K, Foss Dennis L, Donachie William, Mwangi Duncan, Vora Shaunak, Mediratta Sangita, Smith David George Emslie
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals. More specifically, the present invention provides oil emulsions with at least 50 % (v/v) oily phase that may be used with antigens to form vaccine compositions.