Molecular diagnostic test for cancer

Discloses use of a DNA-damage therapeutic agent in the manufacture of a medicament for treating cancer in an individual diagnosed as having a DNA damage response deficient (DDRD) cancer, the individual diagnosed by performing a method comprising measuring expression levels of at least five genes in...

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Bibliographische Detailangaben
Hauptverfasser:	Deharo Steve, Goffard Nicolas, Kennedy Richard, O'donnell Jude, Bylesjo Max, Patterson Fionnuala, Harkin Denis Paul, Hill Laura A, Davison Timothy, Proutski Vitali, Keating Katherine E
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	Discloses use of a DNA-damage therapeutic agent in the manufacture of a medicament for treating cancer in an individual diagnosed as having a DNA damage response deficient (DDRD) cancer, the individual diagnosed by performing a method comprising measuring expression levels of at least five genes in a test sample of tumour cells obtained previously from the individual to derive a combined test score, wherein at least five of the genes are selected from the 44 genes in Table 2B; wherein the individual is diagnosed as having a DDRD cancer when the combined test score of the test sample exceeds a threshold score comprising information correlating the combined test score and the presence of a DDRD cancer, and said exceeding occurs if the combined test score, based on the increased combined expression level of the at least five of the genes that are selected from Table 2B, exceeds the threshold score that is based on the same genes.