Tetrahydropyrrolothiazine compounds

The present invention provides a compound of Formula (I): wherein R is H or F; and A is:(A), (B), (C) or (D); or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of BACE. Disclosed is the use of the compounds in the treatment or prevention of neurodegenerative diseases caused...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Watson, Brian Morgan, Green, Steven James, Mergott, Dustin James, Winneroski Jr., Leonard Larry
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound of Formula (I): wherein R is H or F; and A is:(A), (B), (C) or (D); or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of BACE. Disclosed is the use of the compounds in the treatment or prevention of neurodegenerative diseases caused by Aβ peptides, particularly Alzheimer's disease.