Trk-inhibiting compound
The invention provides a drug having as the active ingredient a compound having Trk-inhibiting activity in the prevention and/or treatment of Trk-associated diseases, for example, pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, an...
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| creator | Takeuchi, Jun Ikura, Masahiro Higashino, Masato Nagaura, Takeshi Yasuhiro, Tetsuya Itadani, Satoshi Hashimura, Kazuya |
| description | The invention provides a drug having as the active ingredient a compound having Trk-inhibiting activity in the prevention and/or treatment of Trk-associated diseases, for example, pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and the like. A compound shown by general formula (I) (in the formula, all symbols represent the same meanings as the symbols in the specification), a salt thereof, N-oxide thereof, solvate thereof, or a prodrug of these is useful as a drug component having Trk-inhibiting activity in the prevention and/or treatment of pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and other such conditions. |
| format | Patent |
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A compound shown by general formula (I) (in the formula, all symbols represent the same meanings as the symbols in the specification), a salt thereof, N-oxide thereof, solvate thereof, or a prodrug of these is useful as a drug component having Trk-inhibiting activity in the prevention and/or treatment of pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and other such conditions.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200828&DB=EPODOC&CC=NZ&NR=711119A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200828&DB=EPODOC&CC=NZ&NR=711119A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Takeuchi, Jun</creatorcontrib><creatorcontrib>Ikura, Masahiro</creatorcontrib><creatorcontrib>Higashino, Masato</creatorcontrib><creatorcontrib>Nagaura, Takeshi</creatorcontrib><creatorcontrib>Yasuhiro, Tetsuya</creatorcontrib><creatorcontrib>Itadani, Satoshi</creatorcontrib><creatorcontrib>Hashimura, Kazuya</creatorcontrib><title>Trk-inhibiting compound</title><description>The invention provides a drug having as the active ingredient a compound having Trk-inhibiting activity in the prevention and/or treatment of Trk-associated diseases, for example, pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and the like. A compound shown by general formula (I) (in the formula, all symbols represent the same meanings as the symbols in the specification), a salt thereof, N-oxide thereof, solvate thereof, or a prodrug of these is useful as a drug component having Trk-inhibiting activity in the prevention and/or treatment of pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and other such conditions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAPKcrWzczLyEzKLMnMS1dIzs8tyC_NS-FhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfF-UeaGQGDpaExQAQAaWSD2</recordid><startdate>20200828</startdate><enddate>20200828</enddate><creator>Takeuchi, Jun</creator><creator>Ikura, Masahiro</creator><creator>Higashino, Masato</creator><creator>Nagaura, Takeshi</creator><creator>Yasuhiro, Tetsuya</creator><creator>Itadani, Satoshi</creator><creator>Hashimura, Kazuya</creator><scope>EVB</scope></search><sort><creationdate>20200828</creationdate><title>Trk-inhibiting compound</title><author>Takeuchi, Jun ; Ikura, Masahiro ; Higashino, Masato ; Nagaura, Takeshi ; Yasuhiro, Tetsuya ; Itadani, Satoshi ; Hashimura, Kazuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ711119A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Takeuchi, Jun</creatorcontrib><creatorcontrib>Ikura, Masahiro</creatorcontrib><creatorcontrib>Higashino, Masato</creatorcontrib><creatorcontrib>Nagaura, Takeshi</creatorcontrib><creatorcontrib>Yasuhiro, Tetsuya</creatorcontrib><creatorcontrib>Itadani, Satoshi</creatorcontrib><creatorcontrib>Hashimura, Kazuya</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Takeuchi, Jun</au><au>Ikura, Masahiro</au><au>Higashino, Masato</au><au>Nagaura, Takeshi</au><au>Yasuhiro, Tetsuya</au><au>Itadani, Satoshi</au><au>Hashimura, Kazuya</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Trk-inhibiting compound</title><date>2020-08-28</date><risdate>2020</risdate><abstract>The invention provides a drug having as the active ingredient a compound having Trk-inhibiting activity in the prevention and/or treatment of Trk-associated diseases, for example, pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and the like. A compound shown by general formula (I) (in the formula, all symbols represent the same meanings as the symbols in the specification), a salt thereof, N-oxide thereof, solvate thereof, or a prodrug of these is useful as a drug component having Trk-inhibiting activity in the prevention and/or treatment of pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, inflammatory bowel disease, Chagas disease, and other such conditions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Trk-inhibiting compound |
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