Macrolide derivatives, preparation thereof and therapeutic use thereof

The present invention relates to macrolide derivatives, and to the preparation and therapeutic use thereof. The compounds according to the present invention have substantial bacteriostatic and/or bactericidal antimicrobial activity, mainly on gram-positive microorganisms. The compounds also act on mycobacteria, especially against strains of sensitive Mycobacterium or Corynebacterium that are resistant to the first-line antibiotics and in the treatment of tuberculosis. In particular, the patent application relates to compounds of formula (I) below, and to a process for preparing them and to the therapeutic use thereof.